Proteases have evolved to mediate the hydrolysis of peptide bonds but may perform transpeptidation in the presence of a proper nucleophilic molecule that can effectively compete with Cleansing Sponge water to react with the acyl-enzyme intermediate.There have been several examples of protease-mediated transpeptidation, but they are generally ineffi
We followed the presence of Zika virus (ZIKV) in four healthy adults (two men and two women), for periods ranging from 78 to 298 days post symptom onset.The patients were evaluated regarding the presence of the virus in different body fluids (blood, saliva, urine and semen), development of immune responses (including antibodies, cytokines and chemo
Over 80% of patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed at a late stage and are locally advanced or with concurrent metastases.The aggressive phenotype and relative chemo- and radiotherapeutic resistance of PDAC is thought to be mediated largely by its prominent stroma, which is supported by an extracellular matrix (ECM).The
Made in the USA Dog Treats This research, using online qualitative survey questions, explored how players of the PlayStation 4 console game, Horizon Zero Dawn, formed emotional attachments to characters while playing as, and assuming the persona of the female player-character, Aloy.It was found that the respondents (approximately 71% male) formed e
Objective To determine the prevalence of unmet need for primary healthcare and associated individual and household-level factors in Kenya.Design The data for this study are drawn from the 2016 Kenya Integrated Household Budget Survey (KIHBS).A multistage sampling technique involving a systematic selection of clusters at the national level and final